Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.69 |
| ▸ | SYK | P43405 | 5/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | TACR2 | P21452 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 6/20 | 0.41 |
| ▸ | CCR4 | P51679 | 4/20 | 0.40 |
| ▸ | IDH2 | P48735 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1326489 | 0.92 | LRRK2 (0.58) | LRRK2SYKJAK2JAK1TYK2 | |
| SCHEMBL1298616 | 0.89 | LRRK2 (0.65) | LRRK2SYKJAK2JAK1TYK2 | |
| SCHEMBL1298193 | 0.87 | LRRK2 (0.53) | LRRK2SYKJAK2BRAF | |
| SCHEMBL1298858 | 0.87 | LRRK2 (0.53) | LRRK2SYKJAK2JAK1BRAF | |
| SCHEMBL1298717 | 0.87 | LRRK2 (0.72) | LRRK2SYKJAK2JAK1TYK2 | |
| SCHEMBL1299124 | 0.87 | LRRK2 (0.62) | LRRK2SYKJAK2JAK1TYK2 | |
| SCHEMBL12655408 | 0.86 | LRRK2 (0.61) | LRRK2SYKJAK2JAK1TYK2 | |
| SCHEMBL1298574 | 0.85 | LRRK2 (0.62) | LRRK2SYKJAK2JAK1TYK2 | |
| SCHEMBL12106931 | 0.84 | LRRK2 (0.62) | LRRK2SYKJAK2JAK1TYK2 | |
| SCHEMBL1298748 | 0.84 | LRRK2 (0.68) | LRRK2SYKJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404677-B2 | Kinase inhibitors | GENOSCO (US) | 2013-03-26 | — | — | US | claimed |
| US-20110269739-A1 | KINASE INHIBITORS | OSCOTEC, INC. (KR) | 2011-11-03 | — | — | US | claimed |
| US-8404677-B2 | Kinase inhibitors | GENOSCO (US) | 2013-03-26 | — | — | US | disclosed |
| US-8404677-B2 | Kinase inhibitors | GENOSCO (US) | 2013-03-26 | — | — | US | disclosed |
| US-8404677-B2 | Kinase inhibitors | GENOSCO (US) | 2013-03-26 | — | — | US | disclosed |
| US-20110269739-A1 | KINASE INHIBITORS | OSCOTEC, INC. (KR) | 2011-11-03 | — | — | US | disclosed |
| US-20110269739-A1 | KINASE INHIBITORS | OSCOTEC, INC. (KR) | 2011-11-03 | — | — | US | disclosed |
| US-20110269739-A1 | KINASE INHIBITORS | OSCOTEC, INC. (KR) | 2011-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269739-A1 | KINASE INHIBITORS | JAK1, LCK, MAP3K20 | LRRK2 436/4885SYK 278/4885JAK2 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.