Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 15/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ICOSLG | O75144 | 1/20 | 0.36 |
| ▸ | ICOS | Q9Y6W8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1803110 | 0.86 | CHUK (0.50) | CHUKFGFR1FLT1 | |
| SCHEMBL12619346 | 0.74 | ICOSLG (0.55) | CHUKGAAMAPTSMN1; SMN2ICOSLG | |
| SCHEMBL1799925 | 0.74 | CHUK (0.61) | CHUKSMN1; SMN2ICOSLGICOS | |
| SCHEMBL1800230 | 0.73 | CHUK (0.59) | CHUKSMN1; SMN2ICOSLGICOS | |
| SCHEMBL12619354 | 0.73 | CHUK (0.67) | CHUKJAK2SMN1; SMN2ICOSLGICOS | |
| SCHEMBL1802859 | 0.71 | CHUK (0.57) | CHUKSMN1; SMN2ICOSLGICOS | |
| SCHEMBL1796756 | 0.71 | CHUK (0.76) | CHUKICOSLGICOS | |
| SCHEMBL30342051 | 0.71 | CHUK (0.76) | CHUKICOSLGICOS | |
| SCHEMBL14253045 | 0.70 | CHUK (1.00) | CHUKICOSLGICOS | |
| SCHEMBL1800241 | 0.69 | CHUK (0.51) | CHUKFGFR1FLT1ICOSLGICOS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2206713-A1 | Beta-carbolines useful for treating inflammatory disease | Millennium Pharmaceuticals, Inc. (US) | 2010-07-14 | — | — | EP | disclosed |