Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.62 |
| ▸ | PIK3R2 | O00459 | 19/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 19/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 19/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 19/20 | 0.62 |
| ▸ | PIK3R5 | Q8WYR1 | 19/20 | 0.62 |
| ▸ | PIK3R3 | Q92569 | 19/20 | 0.62 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12276321 | 0.89 | PIK3CD (0.75) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL18082706 | 0.81 | CCNA2 (0.56) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL12606 | 0.77 | PIK3CD (1.00) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7185 | 0.76 | PIK3CD (0.74) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL8167 | 0.76 | PIK3CD (0.74) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7516 | 0.75 | PIK3CD (0.57) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7170 | 0.74 | PIK3CD (0.71) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7202 | 0.74 | PIK3CD (0.76) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL12984 | 0.73 | PIK3CD (0.73) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL12275160 | 0.70 | PIK3CD (0.73) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |