Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pitavastatin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR known ✓ | P04035 | 5/20 | 0.85 |
| ▸ | PDE4D | Q08499 | 3/20 | 1.00 |
| ▸ | NR4A2 | P43354 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 1.00 |
| ▸ | RXRA | P19793 | 3/20 | 0.85 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.54 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.54 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.54 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | CCKAR | P32238 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.54 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pitavastatin SCHEMBL1582325 | 1.00 | PDE4D (1.00) | PDE4DNR4A2NR1I2HMGCRRXRA | |
| Pitavastatin SCHEMBL6068297 | 1.00 | PDE4D (1.00) | PDE4DNR4A2NR1I2HMGCRRXRA | |
| Pitavastatin SCHEMBL2878734 | 1.00 | PDE4D (1.00) | PDE4DNR4A2NR1I2HMGCRRXRA | |
| Pitavastatin SCHEMBL13278896 | 1.00 | PDE4D (1.00) | PDE4DNR4A2NR1I2HMGCRRXRA | |
| Pitavastatin SCHEMBL6068293 | 1.00 | PDE4D (1.00) | PDE4DNR4A2NR1I2HMGCRRXRA | |
| Pitavastatin SCHEMBL1582328 | 1.00 | PDE4D (1.00) | PDE4DNR4A2NR1I2HMGCRRXRA | |
| Pitavastatin SCHEMBL2878610 | 1.00 | PDE4D (1.00) | PDE4DNR4A2NR1I2HMGCRRXRA | |
| Pitavastatin SCHEMBL13278898 | 1.00 | PDE4D (1.00) | PDE4DNR4A2NR1I2HMGCRRXRA | |
| Pitavastatin SCHEMBL2878736 | 1.00 | PDE4D (1.00) | PDE4DNR4A2NR1I2HMGCRRXRA | |
| Pitavastatin SCHEMBL3369 | 1.00 | PDE4D (1.00) | PDE4DNR4A2NR1I2HMGCRRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012140490-A2 | PROCESS FOR PREPARING QUINOLINE DERIVATIVE | AUROBINDO PHARMA LIMITED (IN) | 2012-10-18 | — | — | WO | disclosed |