Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.46 |
| ▸ | EED | O75530 | 1/20 | 0.42 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.42 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.42 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.42 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30356454 | 1.00 | EZH2 (0.46) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL31729581 | 0.89 | EZH2 (0.46) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16740904 | 0.89 | EZH2 (0.46) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL13279891 | 0.88 | EZH2 (0.41) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL23302592 | 0.82 | EZH2 (0.52) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL30777398 | 0.81 | PARP1 (0.39) | EZH2 | |
| SCHEMBL30499098 | 0.81 | EZH2 (0.59) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL17302561 | 0.80 | EZH2 (0.45) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL15829983 | 0.80 | SLC6A4 (0.45) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL16217341 | 0.75 | EZH2 (0.39) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697198-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2014-02-19 | — | — | EP | disclosed |
| WO-2012142513-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2012-10-18 | — | — | WO | disclosed |