Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.34 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.34 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15710476 | 0.90 | PDE4B (0.40) | BTKPIK3CAMTORPRKDCKDM4D | |
| SCHEMBL13467831 | 0.88 | BTK (0.48) | BTKPIK3CAMTORPRKDCKDM1A | |
| SCHEMBL15711089 | 0.88 | BTK (0.48) | BTKPIK3CAMTORPRKDCKDM1A | |
| SCHEMBL13280218 | 0.83 | EZH2 (0.43) | BTKPIK3CAMTORPRKDCDRD2 | |
| SCHEMBL13279726 | 0.81 | BTK (0.42) | BTKPIK3CAMTORPRKDCKDM1A | |
| SCHEMBL13280637 | 0.81 | BTK (0.42) | BTKPIK3CAMTORPRKDCKDM1A | |
| SCHEMBL15732184 | 0.80 | BTK (0.40) | BTKPIK3CAMTORPRKDCKDM1A | |
| SCHEMBL13276862 | 0.80 | BTK (0.40) | BTKPIK3CAMTORPRKDCKDM1A | |
| SCHEMBL15710041 | 0.80 | BTK (0.40) | BTKKDM1AMAOBDRD2DRD3 | |
| SCHEMBL15709992 | 0.80 | BTK (0.48) | BTKPIK3CAMTORPRKDCKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697198-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2014-02-19 | — | — | EP | disclosed |
| WO-2012142513-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2012-10-18 | — | — | WO | disclosed |