SCHEMBL13282200

SCHEMBL13282200

CC1C=CC(=O)NC1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2047805 0.75
SCHEMBL22553392 0.71
SCHEMBL10053663 0.69 CYP2C19 (0.33)
SCHEMBL28724378 0.67 CRBN (0.35)
SCHEMBL24035038 0.66 CYP2C19 (0.33)
SCHEMBL17867285 0.66
SCHEMBL24035287 0.63 CRBN (0.39)
SCHEMBL9066143 0.62
SCHEMBL13508673 0.62
SCHEMBL1074428 0.62

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11485725-B2 Derivatives of piperlongumine and uses thereof AURANSA INC. (US) 2022-11-01 US disclosed
US-20210198235-A1 DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF AURANSA INC. 2021-07-01 US disclosed
EP-3251679-B1 NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST SODIUM-DEPENDANT GLUCOSE TRANSPORTER MITSUBISHI TANABE PHARMA CORP (JP) 2020-12-16 EP disclosed
US-20200377510-A1 DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF AURANSA INC. 2020-12-03 US disclosed
US-20200377510-A1 DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF AURANSA INC. 2020-12-03 US disclosed
WO-2019103897-A1 DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF AURANSA INC. (US) 2019-05-31 WO disclosed
WO-2015027963-A1 AROMATIC RING DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF 四川海思科制药有限公司 (CN) 2015-03-05 WO disclosed
WO-2014206349-A1 OXA-THIA-BICYCLO[3.2.1]OCTANE DERIVATIVE, PREPARATION METHOD, AND USE OF SAME 四川海思科制药有限公司 (CN) 2014-12-31 WO disclosed
WO-2010075273-A1 BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF SCHERING CORPORATION (US) 2010-07-01 WO disclosed