Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 18/20 | 0.37 |
| ▸ | PPARA | Q07869 | 5/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13114529 | 0.90 | PPARG (0.42) | PPARGPPARAPPARD | |
| SCHEMBL13282970 | 0.86 | NR1H2 (0.37) | PPARGPPARAPPARDNR1H2NR1H3 | |
| SCHEMBL3544506 | 0.84 | PPARG (0.40) | PPARGPPARAPPARDNR1H2NR1H3 | |
| SCHEMBL3545932 | 0.83 | PPARG (0.39) | PPARGPPARAPPARDNR1H2NR1H3 | |
| SCHEMBL5174877 | 0.83 | PPARG (0.47) | PPARGPPARAPPARDCYP3A4CYP2C8 | |
| SCHEMBL5175346 | 0.83 | PPARG (0.47) | PPARGPPARAPPARD | |
| SCHEMBL13114511 | 0.82 | PPARG (0.40) | PPARGPPARAPPARDNR1H2NR1H3 | |
| SCHEMBL14528080 | 0.81 | PPARG (0.39) | PPARGPPARAPPARD | |
| SCHEMBL3549278 | 0.81 | PPARG (0.41) | PPARGPPARAPPARDNR1H2NR1H3 | |
| SCHEMBL3545012 | 0.81 | PPARG (0.40) | PPARGPPARAPPARDNR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168164-A1 | Antidiabetic Oxazolidinediones and Thiazolidinediones | MERCK SHARP & DOHME CORP. | 2010-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168164-A1 | Antidiabetic Oxazolidinediones and Thiazolidinediones | PPARD, PPARA, PPARG | PPARG 3/4885PPARA 2/4885PPARD 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.