Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.38 |
| ▸ | MBOAT4 | Q96T53 | 3/20 | 0.36 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.36 |
| ▸ | GUCY1B2 | O75343 | 2/20 | 0.34 |
| ▸ | GUCY1A2 | P33402 | 2/20 | 0.34 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.34 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | PDE6D | O43924 | 1/20 | 0.32 |
| ▸ | PDE6A | P16499 | 1/20 | 0.32 |
| ▸ | PDE6G | P18545 | 1/20 | 0.32 |
| ▸ | PDE6B | P35913 | 1/20 | 0.32 |
| ▸ | PDE6C | P51160 | 1/20 | 0.32 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1327500 | 0.88 | C5AR1 (0.34) | C5AR1GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL1327784 | 0.83 | FFAR1 (0.37) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1FFAR1 | |
| SCHEMBL1329945 | 0.83 | NR1H4 (0.36) | MRGPRX4CRHR1FFAR4 | |
| SCHEMBL1327299 | 0.83 | C5AR1 (0.46) | MRGPRX4MBOAT4C5AR1FFAR4FFAR1 | |
| SCHEMBL1329946 | 0.83 | MRGPRX4 (0.39) | MRGPRX4FFAR4 | |
| SCHEMBL1328748 | 0.82 | MRGPRX4 (0.42) | MRGPRX4MBOAT4C5AR1GUCY1B2GUCY1A2 | |
| SCHEMBL1329052 | 0.79 | MRGPRX4 (0.36) | MRGPRX4FFAR4 | |
| SCHEMBL1328324 | 0.77 | PPARG (0.36) | FFAR1 | |
| SCHEMBL1328029 | 0.77 | C5AR1 (0.39) | MRGPRX4MBOAT4C5AR1GUCY1B2GUCY1A2 | |
| SCHEMBL1329216 | 0.77 | CD274 (0.33) | C5AR1CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342115-B2 | Binding antagonist and arylpyridine for antiinflammatory agents, cardiovascular disorders and antagonist or agonist and for immunology | NEUROGEN CORPORATION (US) | 2008-03-11 | — | — | US | claimed |
| US-20110281837-A1 | 3-SUBSTITUTED-6-ARYL PYRIDINES | HUTCHINSON ALAN J (US) | 2011-11-17 | — | — | US | disclosed |
| US-7863454-B2 | 3-substituted-6-aryl pyridines | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2011-01-04 | — | — | US | disclosed |
| US-20090176980-A1 | 3-Substituted-6-Aryl Pyridines | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2009-07-09 | — | — | US | disclosed |
| US-7342115-B2 | Binding antagonist and arylpyridine for antiinflammatory agents, cardiovascular disorders and antagonist or agonist and for immunology | NEUROGEN CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281837-A1 | 3-SUBSTITUTED-6-ARYL PYRIDINES | C3AR1, C5AR1, C5AR2 | MRGPRX4 30/4885MBOAT4 4290/4885C5AR1 2/4885 |
| US-20090176980-A1 | 3-Substituted-6-Aryl Pyridines | C3AR1, C5AR1, C5AR2 | MRGPRX4 30/4885MBOAT4 4290/4885C5AR1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.