Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.91 |
| ▸ | KDR | P35968 | 3/20 | 0.66 |
| ▸ | FLT4 | P35916 | 2/20 | 0.66 |
| ▸ | BRAF | P15056 | 2/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.66 |
| ▸ | CIT | O14578 | 1/20 | 0.66 |
| ▸ | GAK | O14976 | 1/20 | 0.66 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.66 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.66 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.66 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.66 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.66 |
| ▸ | STK17B | O94768 | 1/20 | 0.66 |
| ▸ | STK10 | O94804 | 1/20 | 0.66 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.66 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.66 |
| ▸ | ABL1 | P00519 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23258972 | 0.90 | EGFR (0.80) | EGFRKDRFLT4BRAFERBB2 | |
| SCHEMBL23258971 | 0.90 | EGFR (0.79) | EGFRKDRFLT4BRAFERBB2 | |
| SCHEMBL15536133 | 0.90 | EGFR (0.79) | EGFRKDRFLT4BRAFERBB2 | |
| SCHEMBL10109111 | 0.88 | EGFR (0.77) | EGFRKDRFLT4BRAFERBB2 | |
| SCHEMBL25658063 | 0.87 | EGFR (0.84) | EGFRKDRFLT4BRAFERBB2 | |
| SCHEMBL5675017 | 0.85 | EGFR (0.72) | EGFRKDRFLT4BRAFERBB2 | |
| SCHEMBL13319080 | 0.83 | EGFR (0.71) | EGFRKDRFLT4BRAFERBB2 | |
| SCHEMBL5675010 | 0.82 | EGFR (0.68) | EGFRKDRFLT4BRAFERBB2 | |
| SCHEMBL5084456 | 0.82 | EGFR (0.67) | EGFRKDRFLT4BRAFERBB2 | |
| SCHEMBL1396666 | 0.81 | EGFR (0.66) | EGFRKDRFLT4BRAFERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013180403-A1 | PROCESS FOR PREPARING GEFITINIB AND AN INTERMEDIATE USED FOR PREPARING THEREOF | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2013-12-05 | — | — | WO | disclosed |
| WO-2010076810-A2 | A PROCESS FOR THE PREPARATION OF GEFITINIB | IND-SWIFT LABORATORIES LIMITED (IN) | 2010-07-08 | — | — | WO | disclosed |