Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.82 |
| ▸ | JAK1 | P23458 | 5/20 | 0.77 |
| ▸ | TYK2 | P29597 | 5/20 | 0.77 |
| ▸ | JAK3 | P52333 | 5/20 | 0.77 |
| ▸ | BTK | Q06187 | 4/20 | 0.66 |
| ▸ | BRD4 | O60885 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL142857 | 0.94 | JAK2 (0.86) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL144049 | 0.90 | JAK2 (1.00) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL139658 | 0.90 | JAK2 (0.81) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL142840 | 0.89 | JAK2 (0.88) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL142260 | 0.88 | JAK2 (1.00) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL142428 | 0.88 | JAK2 (0.89) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL145081 | 0.88 | JAK2 (0.80) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL143045 | 0.87 | JAK2 (0.80) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL140477 | 0.87 | JAK2 (1.00) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL143790 | 0.86 | JAK2 (0.81) | JAK2JAK1TYK2JAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010080474-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-15 | — | — | WO | disclosed |