Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 11/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.33 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | SCD | O00767 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TKT | P29401 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2546500 | 0.91 | PTPRB (0.34) | PTPRBATMKCNQ3KCNQ2KCNQ4 | |
| SCHEMBL2549397 | 0.91 | PTPRB (0.34) | PTPRBATMKCNQ3KCNQ2KCNQ4 | |
| SCHEMBL2549301 | 0.88 | PTPRB (0.33) | PTPRBATM | |
| SCHEMBL1743510 | 0.88 | PTPRB (0.33) | PTPRBATM | |
| SCHEMBL2547638 | 0.84 | ATM (0.36) | PTPRBATMCYP3A4 | |
| SCHEMBL2547634 | 0.84 | ATM (0.36) | PTPRBATMCYP3A4 | |
| SCHEMBL2550153 | 0.84 | ATM (0.35) | PTPRBATMKCNQ3KCNQ2KCNQ4 | |
| SCHEMBL2550148 | 0.84 | ATM (0.35) | PTPRBATMKCNQ3KCNQ2KCNQ4 | |
| SCHEMBL4298661 | 0.84 | ATM (0.35) | PTPRBATMKCNQ3KCNQ2KCNQ4 | |
| SCHEMBL1744963 | 0.82 | ATM (0.34) | PTPRBATMCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083246-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2010-07-22 | — | — | WO | disclosed |