Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 4/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 4/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.32 |
| ▸ | WNT1 | P04628 | 2/20 | 0.31 |
| ▸ | PTPRB | P23467 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12241689 | 0.93 | PDPK1 (0.36) | PDPK1GSK3BDYRK1ASYKAAK1 | |
| SCHEMBL2545072 | 0.89 | AKT1 (0.38) | AKT1CDK2GSK3BDYRK1ASYK | |
| SCHEMBL2545074 | 0.89 | AKT1 (0.38) | AKT1CDK2GSK3BDYRK1ASYK | |
| SCHEMBL2549646 | 0.86 | AKT1 (0.42) | AKT1CDK2PDPK1GSK3BDYRK1A | |
| SCHEMBL1744751 | 0.84 | CDK2 (0.35) | AKT1CDK2PDPK1GSK3BDYRK1A | |
| SCHEMBL2546671 | 0.84 | CDK2 (0.35) | AKT1CDK2PDPK1GSK3BDYRK1A | |
| SCHEMBL12241690 | 0.82 | PDPK1 (0.34) | PDPK1GSK3BDYRK1ASYKAAK1 | |
| SCHEMBL12266702 | 0.81 | AKT1 (0.42) | AKT1CDK2 | |
| SCHEMBL2544075 | 0.80 | CDK2 (0.34) | AKT1CDK2GSK3BDYRK1APPARG | |
| SCHEMBL2547011 | 0.80 | CDK2 (0.34) | AKT1CDK2GSK3BDYRK1APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083246-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2010-07-22 | — | — | WO | disclosed |