Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP46A1 | Q9Y6A2 | 5/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL791535 | 0.82 | SMN1; SMN2 (0.41) | CYP46A1CYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL13285986 | 0.80 | KDM4E (0.34) | CYP46A1CYP11B1CYP11B2RAB9AMAPT | |
| SCHEMBL12936660 | 0.77 | CDK2 (0.50) | CYP11B1CYP11B2NPC1RAB9AGSK3B | |
| SCHEMBL792166 | 0.74 | CYP11B1 (0.54) | CYP46A1CYP11B1CYP11B2ALDH1A1KDM4E | |
| SCHEMBL25871395 | 0.74 | CYP46A1 (0.54) | CYP46A1CYP11B2MEN1KMT2ANPC1 | |
| SCHEMBL3422005 | 0.74 | CYP46A1 (0.54) | CYP46A1CYP11B2MEN1KMT2ANPC1 | |
| SCHEMBL22241332 | 0.74 | CYP46A1 (0.55) | CYP46A1CYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL792013 | 0.73 | FFAR1 (0.53) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL13393498 | 0.72 | NPC1 (0.60) | CYP46A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL8256542 | 0.72 | KDM4E (0.41) | MEN1KMT2AMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2206715-A1 | Fused heterotetracyclic compounds and use thereof as hcv polymerase inhibitor | Japan Tobacco, Inc. (JP) | 2010-07-14 | — | — | EP | disclosed |