Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.63 |
| ▸ | AGPAT2 | O15120 | 4/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | POLA1 | P09884 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8333105 | 0.92 | ROCK1 (0.76) | ROCK1AGPAT2MAPKAPK2ROCK2TNIK | |
| SCHEMBL8326979 | 0.90 | ROCK1 (0.63) | ROCK1AGPAT2MAPKAPK2ROCK2KDR | |
| SCHEMBL8325985 | 0.89 | ROCK1 (0.66) | ROCK1AGPAT2MAPKAPK2ROCK2KDR | |
| SCHEMBL8329571 | 0.89 | ROCK1 (0.71) | ROCK1AGPAT2MAPKAPK2ROCK2KDR | |
| SCHEMBL13288434 | 0.88 | ROCK1 (0.81) | ROCK1AGPAT2MAPKAPK2ROCK2KDR | |
| SCHEMBL13288436 | 0.86 | ROCK1 (0.59) | ROCK1AGPAT2MAPKAPK2ROCK2KDR | |
| SCHEMBL13288483 | 0.85 | ROCK1 (0.61) | ROCK1AGPAT2MAPKAPK2ROCK2PIK3CA | |
| SCHEMBL8323576 | 0.85 | ROCK1 (0.61) | ROCK1AGPAT2MAPKAPK2ROCK2PIK3CA | |
| SCHEMBL13288477 | 0.81 | ROCK1 (0.76) | ROCK1AGPAT2MAPKAPK2ROCK2KDR | |
| SCHEMBL8328328 | 0.80 | ROCK1 (0.85) | ROCK1AGPAT2MAPKAPK2ROCK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737153-B2 | Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-15 | — | — | US | disclosed |
| US-7737153-B2 | Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-15 | — | — | US | disclosed |