Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.54 |
| ▸ | GSK3B | P49841 | 4/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13119446 | 0.90 | CDK2 (0.68) | CDK2GSK3B | |
| SCHEMBL13119519 | 0.90 | CDK2 (0.68) | CDK2GSK3B | |
| SCHEMBL13119425 | 0.89 | CDK2 (0.69) | CDK2GSK3B | |
| SCHEMBL14545262 | 0.89 | CDK2 (0.45) | CDK2GSK3BALDH1A1HPGDABL1 | |
| SCHEMBL13288881 | 0.88 | CDK2 (0.50) | CDK2GSK3BABL1 | |
| SCHEMBL14613294 | 0.88 | CDK2 (0.46) | CDK2GSK3BUSP2ALDH1A1HPGD | |
| SCHEMBL14581634 | 0.88 | CDK2 (0.49) | CDK2GSK3BABL1 | |
| SCHEMBL13289143 | 0.87 | CDK2 (0.54) | CDK2GSK3BABL1MEN1KMT2A | |
| SCHEMBL13288826 | 0.86 | CDK2 (0.44) | CDK2GSK3BALDH1A1ABL1MEN1 | |
| SCHEMBL13288866 | 0.86 | CDK2 (0.59) | CDK2GSK3BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |