Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.41 |
| ▸ | CDK2 | P24941 | 5/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14418689 | 0.92 | GSK3B (0.53) | GSK3BCHEK1CCNE1CDK2VNN1 | |
| SCHEMBL13288814 | 0.91 | GSK3B (0.61) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL13118848 | 0.91 | GSK3B (0.70) | GSK3BCCNE1CDK2 | |
| SCHEMBL13289043 | 0.89 | GSK3B (0.63) | GSK3BCHEK1CCNE1CDK2VNN1 | |
| SCHEMBL13288827 | 0.87 | GSK3B (0.56) | GSK3BCHEK1CCNE1CDK2NAMPT | |
| SCHEMBL13305370 | 0.86 | GSK3B (0.61) | GSK3BCHEK1CCNE1CDK2VNN1 | |
| SCHEMBL12953848 | 0.86 | GSK3B (0.61) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL13146320 | 0.86 | GSK3B (0.68) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL13289048 | 0.86 | GSK3B (0.59) | GSK3BCHEK1CCNE1CDK2VNN1 | |
| SCHEMBL13288837 | 0.84 | GSK3B (0.57) | GSK3BCHEK1CCNE1CDK2VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |