Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13288941 | 0.91 | KMT2A (0.55) | GSK3BKMT2ATDP1CHEK1POLB | |
| SCHEMBL13120532 | 0.90 | GSK3B (0.66) | GSK3B | |
| SCHEMBL13289389 | 0.87 | GSK3B (0.53) | GSK3BKMT2ATDP1CHEK1POLB | |
| SCHEMBL13288942 | 0.83 | GSK3B (0.53) | GSK3BCHEK1POLB | |
| SCHEMBL13120512 | 0.83 | GSK3B (0.68) | GSK3B | |
| SCHEMBL13288944 | 0.82 | GSK3B (0.48) | GSK3BKMT2ATDP1CHEK1POLB | |
| SCHEMBL13289383 | 0.82 | GSK3B (0.52) | GSK3BTDP1CHEK1TSHR | |
| SCHEMBL13120580 | 0.82 | GSK3B (0.62) | GSK3BKMT2AL3MBTL1 | |
| SCHEMBL12954478 | 0.82 | GSK3B (0.50) | GSK3BKMT2ACHEK1SMN1; SMN2NAMPT | |
| SCHEMBL13289102 | 0.82 | GSK3B (0.50) | GSK3BCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |