Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.46 |
| ▸ | GSK3B | P49841 | 6/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | GPR39 | O43194 | 1/20 | 0.35 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13289016 | 0.94 | CDK2 (0.46) | CDK2GSK3BCCNA2CCNA1RET | |
| SCHEMBL13288909 | 0.93 | CDK2 (0.50) | CDK2GSK3BCCNA2CCNA1RET | |
| SCHEMBL13120803 | 0.91 | CDK2 (0.58) | CDK2GSK3BCCNA2CCNA1 | |
| SCHEMBL13288985 | 0.90 | CDK2 (0.48) | CDK2GSK3BCCNA2CCNA1RET | |
| SCHEMBL13289239 | 0.90 | GSK3B (0.51) | CDK2GSK3BCCNA2CCNA1RET | |
| SCHEMBL13288905 | 0.89 | CDK2 (0.51) | CDK2GSK3BCCNA2CCNA1RET | |
| SCHEMBL14043404 | 0.87 | GSK3B (0.44) | CDK2GSK3BCCNA2CCNA1RET | |
| SCHEMBL13289093 | 0.87 | CDK2 (0.48) | CDK2GSK3BCCNA2CCNA1IDH1 | |
| SCHEMBL13289444 | 0.87 | CDK2 (0.49) | CDK2GSK3BCCNA2CCNA1RET | |
| SCHEMBL13289194 | 0.86 | IDH1 (0.42) | CDK2GSK3BCCNA2CCNA1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |