Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13289285 | 0.95 | MAPK14 (0.44) | GSK3BCCNT1CDK2HSD11B1MAPK14 | |
| SCHEMBL13120938 | 0.89 | GSK3B (0.61) | GSK3BCCNT1CDK2HSD11B1CCND1 | |
| SCHEMBL13289292 | 0.88 | GSK3B (0.47) | GSK3BCDK2HSD11B1MEN1KMT2A | |
| SCHEMBL14545838 | 0.88 | GSK3B (0.46) | GSK3BMEN1KMT2APKMCNR1 | |
| SCHEMBL13289294 | 0.86 | GSK3B (0.44) | GSK3BCDK2HSD11B1MEN1NPC1 | |
| SCHEMBL14545836 | 0.86 | GSK3B (0.43) | GSK3BCDK2HSD11B1MEN1KMT2A | |
| SCHEMBL13289289 | 0.86 | CNR1 (0.43) | GSK3BCDK2HSD11B1PKMCNR1 | |
| SCHEMBL13288949 | 0.86 | GSK3B (0.41) | GSK3BCDK2HSD11B1MAPK14MEN1 | |
| SCHEMBL13289299 | 0.85 | GSK3B (0.42) | GSK3BCDK2HSD11B1MEN1KMT2A | |
| SCHEMBL13289291 | 0.85 | TSHR (0.43) | GSK3BCCNT1CDK2HSD11B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |