Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 20/20 | 0.60 |
| ▸ | LYN | P07948 | 18/20 | 0.60 |
| ▸ | SRC | P12931 | 18/20 | 0.60 |
| ▸ | KDR | P35968 | 18/20 | 0.60 |
| ▸ | HCK | P08631 | 16/20 | 0.60 |
| ▸ | INSR | P06213 | 16/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1830993 | 0.91 | LCK (0.59) | LCKLYNSRCKDRHCK | |
| SCHEMBL3240145 | 0.91 | LCK (0.69) | LCKLYNSRCKDRHCK | |
| SCHEMBL1825118 | 0.89 | LCK (0.74) | LCKLYNSRCKDRHCK | |
| SCHEMBL1822079 | 0.88 | LCK (0.56) | LCKLYNSRCKDRHCK | |
| SCHEMBL1826343 | 0.86 | LCK (0.55) | LCKLYNSRCKDRHCK | |
| SCHEMBL1827988 | 0.86 | LCK (0.58) | LCKLYNSRCKDRHCK | |
| SCHEMBL1824307 | 0.86 | LCK (0.59) | LCKLYNSRCKDRHCK | |
| SCHEMBL1823600 | 0.86 | BRAF (0.59) | LCKLYNSRCKDRHCK | |
| SCHEMBL13292048 | 0.85 | LCK (0.58) | LCKLYNSRCKDRHCK | |
| SCHEMBL1824843 | 0.85 | KDR (0.56) | LCKLYNSRCKDRHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758892-B1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2012-10-17 | — | — | EP | disclosed |
| US-7745437-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2010-06-29 | — | — | US | disclosed |