Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 18/20 | 0.61 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12973519 | 0.89 | TRPV1 (0.66) | TRPV1P2RX3PIK3CD | |
| SCHEMBL13293187 | 0.87 | TRPV1 (0.66) | TRPV1 | |
| SCHEMBL2845333 | 0.86 | TRPV1 (0.67) | TRPV1P2RX3PIK3CD | |
| SCHEMBL2843997 | 0.85 | TRPV1 (0.69) | TRPV1 | |
| SCHEMBL2851097 | 0.85 | TRPV1 (0.71) | TRPV1 | |
| SCHEMBL2854722 | 0.83 | TRPV1 (0.87) | TRPV1 | |
| SCHEMBL14350786 | 0.81 | TRPV1 (0.53) | TRPV1 | |
| SCHEMBL2850967 | 0.80 | TRPV1 (0.60) | TRPV1 | |
| SCHEMBL2848814 | 0.80 | TRPV1 (0.62) | TRPV1 | |
| SCHEMBL12994735 | 0.80 | TRPV1 (0.51) | TRPV1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745451-B2 | 2,3-Difluoro-benzyl)-[6-(5-methyl-pyridin-2-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-yl]-amine, useful for the prevention and treatment of pain, inflammation, cognitive disorders, anxiety and depression in humans | RENOVIS, INC. (US) | 2010-06-29 | — | — | US | disclosed |