Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGK1 | O00141 | 1/20 | 0.55 |
| ▸ | MAP2K4 | P45985 | 14/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.48 |
| ▸ | MAP2K7 | O14733 | 6/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1330605 | 0.78 | NTRK1 (0.53) | AURKA | |
| SCHEMBL13868900 | 0.71 | MAP2K4 (0.68) | SGK1MAP2K4MAP2K7AURKA | |
| SCHEMBL4240954 | 0.66 | SGK1 (0.55) | SGK1MAP2K4MAP2K7AURKA | |
| SCHEMBL27191602 | 0.66 | MAP2K4 (1.00) | MAP2K4MAP2K7 | |
| SCHEMBL1460621 | 0.65 | TTK (0.65) | SGK1MAP2K4MAP2K7AURKATTK | |
| SCHEMBL1330480 | 0.65 | AXL (0.61) | AXL | |
| SCHEMBL27191580 | 0.65 | MAP2K4 (1.00) | MAP2K4MAP2K7 | |
| SCHEMBL1461764 | 0.64 | AURKA (0.61) | SGK1MAP2K4MAP2K7AURKATTK | |
| SCHEMBL1461030 | 0.64 | AURKA (0.67) | SGK1MAP2K4MAP2K7AURKATTK | |
| SCHEMBL27191603 | 0.64 | MAP2K4 (1.00) | MAP2K4MAP2K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293738-B2 | Indazole inhibitors of kinase | ABBOTT LABORATORIES (US) | 2012-10-23 | — | — | US | disclosed |
| US-20110281868-A1 | INDAZOLE INHIBITORS OF KINASE | ABBOTT LABORATORIES (US) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281868-A1 | INDAZOLE INHIBITORS OF KINASE | AURKA, AURKC, AURKB | SGK1 477/4885MAP2K4 247/4885AXL 399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.