Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 17/20 | 0.45 |
| ▸ | LYN | P07948 | 17/20 | 0.45 |
| ▸ | SRC | P12931 | 17/20 | 0.45 |
| ▸ | KDR | P35968 | 17/20 | 0.45 |
| ▸ | HCK | P08631 | 15/20 | 0.45 |
| ▸ | INSR | P06213 | 15/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13301782 | 0.91 | LCK (0.47) | LCKLYNSRCKDRHCK | |
| SCHEMBL13301928 | 0.90 | LCK (0.47) | LCKLYNSRCKDRHCK | |
| SCHEMBL1824860 | 0.88 | BRAF (0.58) | LCKLYNSRCKDRHCK | |
| SCHEMBL13301994 | 0.88 | HCK (0.44) | LCKLYNSRCKDRHCK | |
| SCHEMBL13301821 | 0.87 | LCK (0.45) | LCKLYNSRCKDRHCK | |
| SCHEMBL13301827 | 0.86 | LCK (0.45) | LCKLYNSRCKDRHCK | |
| SCHEMBL13301979 | 0.86 | LCK (0.54) | LCKLYNSRCKDRHCK | |
| SCHEMBL13301997 | 0.85 | LCK (0.46) | LCKLYNSRCKDRHCK | |
| SCHEMBL13301730 | 0.84 | MAPK14 (0.52) | HCKBRAFBTK | |
| SCHEMBL13302020 | 0.83 | LCK (0.45) | LCKLYNSRCKDRHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745437-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2010-06-29 | — | — | US | disclosed |