Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCK | P08631 | 9/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | INSR | P06213 | 4/20 | 0.43 |
| ▸ | LCK | P06239 | 4/20 | 0.43 |
| ▸ | LYN | P07948 | 4/20 | 0.43 |
| ▸ | SRC | P12931 | 4/20 | 0.43 |
| ▸ | NR2C2 | P49116 | 5/20 | 0.41 |
| ▸ | CDK8 | P49336 | 3/20 | 0.41 |
| ▸ | RET | P07949 | 3/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.41 |
| ▸ | FES | P07332 | 2/20 | 0.41 |
| ▸ | FER | P16591 | 2/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | STK25 | O00506 | 1/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13301899 | 0.93 | HCK (0.48) | HCKBTKKDRINSRLCK | |
| SCHEMBL1825454 | 0.91 | HCK (0.52) | HCKKDRINSRLCKLYN | |
| SCHEMBL13301943 | 0.87 | BRAF (0.51) | HCKKDRINSRLCKLYN | |
| SCHEMBL13269711 | 0.87 | HCK (0.58) | HCKBTKKDRINSRLCK | |
| SCHEMBL1826484 | 0.85 | NR2C2 (0.58) | HCKNR2C2MAP3K7FESFER | |
| SCHEMBL3234828 | 0.84 | NR2C2 (0.59) | HCKNR2C2MAP3K7FESFER | |
| SCHEMBL13301710 | 0.82 | HCK (0.51) | HCKBTKKDRINSRLCK | |
| SCHEMBL13302014 | 0.82 | HCK (0.53) | HCKBTKKDRINSRLCK | |
| SCHEMBL17470236 | 0.81 | HCK (0.48) | HCKBTKKDRINSRLCK | |
| SCHEMBL13291968 | 0.81 | CSF1R (0.57) | HCKBTKKDRINSRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745437-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2010-06-29 | — | — | US | disclosed |