Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.60 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 9/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.51 |
| ▸ | CDK9 | P50750 | 5/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.46 |
| ▸ | CDK1 | P06493 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | CDK7 | P50613 | 2/20 | 0.43 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CCNK | O75909 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13305316 | 0.91 | CDK2 (0.55) | CDK2CCNA2CCNA1GSK3BCCNE1 | |
| SCHEMBL13305033 | 0.89 | CDK2 (0.58) | CDK2CCNA2CCNA1GSK3BCCNE1 | |
| SCHEMBL12952883 | 0.88 | CDK2 (0.76) | CDK2CCNA2CCNA1GSK3BCCNE1 | |
| SCHEMBL13304889 | 0.87 | CDK2 (0.51) | CDK2CCNA2CCNA1GSK3BCCNE1 | |
| SCHEMBL13304615 | 0.87 | CDK2 (0.64) | CDK2CCNA2CCNA1GSK3BCCNE1 | |
| SCHEMBL13305012 | 0.87 | CDK2 (0.71) | CDK2CCNA2CCNA1GSK3BCCNE1 | |
| SCHEMBL13304605 | 0.85 | CDK2 (0.55) | CDK2CCNA2CCNA1GSK3BCCNE1 | |
| SCHEMBL13304925 | 0.83 | CDK2 (0.57) | CDK2CCNA2CCNA1GSK3BCCNE1 | |
| SCHEMBL13304886 | 0.82 | CDK2 (0.47) | CDK2CCNA2CCNA1GSK3BCCNE1 | |
| SCHEMBL13146048 | 0.81 | GSK3B (0.77) | CDK2GSK3BCCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |