Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.51 |
| ▸ | GSK3B | P49841 | 7/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GPR39 | O43194 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11930877 | 0.91 | CDK2 (0.64) | CDK2GSK3BCCNE1 | |
| SCHEMBL13305382 | 0.80 | CDK2 (0.50) | CDK2GSK3BCCNE1NPC1RAB9A | |
| SCHEMBL5460455 | 0.79 | CDK2 (0.58) | CDK2GSK3BCCNE1NPC1RAB9A | |
| SCHEMBL13304601 | 0.78 | GSK3B (0.53) | CDK2GSK3BCCNE1NPC1RAB9A | |
| SCHEMBL12953818 | 0.78 | CDK2 (0.67) | CDK2GSK3BCCNE1 | |
| SCHEMBL13304789 | 0.78 | CDK2 (0.52) | CDK2GSK3BNPC1RAB9AKMT2A | |
| SCHEMBL12953814 | 0.78 | GSK3B (0.69) | CDK2GSK3BCCNE1 | |
| SCHEMBL12953180 | 0.78 | GSK3B (0.54) | CDK2GSK3BCCNE1NPC1RAB9A | |
| SCHEMBL12953190 | 0.78 | GSK3B (0.77) | CDK2GSK3BCCNE1 | |
| SCHEMBL13305141 | 0.77 | CDK2 (0.55) | CDK2GSK3BCCNE1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |