Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.41 |
| ▸ | CDK2 | P24941 | 5/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 4/20 | 0.39 |
| ▸ | CDK7 | P50613 | 4/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.39 |
| ▸ | CCNH | P51946 | 3/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 3/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.34 |
| ▸ | CDK4 | P11802 | 2/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | GPR39 | O43194 | 1/20 | 0.34 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12952905 | 0.90 | GSK3B (0.65) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13146206 | 0.90 | GSK3B (0.51) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL12953011 | 0.81 | GSK3B (0.63) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13304684 | 0.81 | GSK3B (0.49) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL14412770 | 0.80 | GSK3B (0.67) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13304607 | 0.79 | GSK3B (0.79) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13305377 | 0.77 | CDK2 (0.53) | GSK3BCDK2CCNA2CCNA1GPR39 | |
| SCHEMBL11930866 | 0.74 | GSK3B (0.63) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13305591 | 0.73 | GSK3B (0.52) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13305605 | 0.72 | GSK3B (0.55) | GSK3BCHEK1CDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |