Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13289145 | 0.93 | GSK3B (0.53) | GSK3BCHEK1KMT2AUSP2HPGD | |
| SCHEMBL12953740 | 0.92 | GSK3B (0.64) | GSK3BCCNE1CDK2 | |
| SCHEMBL13289230 | 0.87 | GSK3B (0.52) | GSK3BCHEK1FAAHALDH1A1MAPK1 | |
| SCHEMBL14418661 | 0.87 | GSK3B (0.54) | GSK3BCHEK1FAAHMAPK1HTT | |
| SCHEMBL14043233 | 0.87 | GSK3B (0.56) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL12954095 | 0.86 | GSK3B (0.54) | GSK3BCHEK1KMT2AMAPK1MEN1 | |
| SCHEMBL14043406 | 0.86 | GSK3B (0.56) | GSK3BCHEK1FAAHMAPK1HTT | |
| SCHEMBL13289156 | 0.86 | GSK3B (0.56) | GSK3BCHEK1KMT2AFAAHMEN1 | |
| SCHEMBL13289498 | 0.86 | GSK3B (0.56) | GSK3BCHEK1FAAHCCNE1CDK2 | |
| SCHEMBL13121485 | 0.85 | GSK3B (0.66) | GSK3BCCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |