Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.50 |
| ▸ | CDK2 | P24941 | 5/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13305338 | 0.78 | CDK2 (0.79) | GSK3BCDK2CYP1A2CYP3A4 | |
| SCHEMBL13305616 | 0.77 | GSK3B (0.49) | GSK3BCDK2CHRNB2CHRNA4 | |
| SCHEMBL13288631 | 0.77 | GSK3B (0.65) | GSK3BCDK2CYP1A2CYP3A4 | |
| SCHEMBL13304769 | 0.75 | GSK3B (0.50) | GSK3BCDK2ALDH1A1 | |
| SCHEMBL17690923 | 0.74 | GSK3B (0.48) | GSK3BCDK2CHRNB2CHRNA4 | |
| SCHEMBL13305416 | 0.73 | AIMP2 (0.34) | GSK3BCDK2ALDH1A1MEN1KMT2A | |
| SCHEMBL13304933 | 0.72 | GSK3B (0.40) | GSK3BCYP3A4ALDH1A1L3MBTL1POLB | |
| SCHEMBL13304678 | 0.71 | GSK3B (0.67) | GSK3BCDK2 | |
| SCHEMBL13289903 | 0.71 | GSK3B (0.48) | GSK3BCDK2CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL14301242 | 0.70 | GSK3B (0.74) | GSK3BCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |