Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.58 |
| ▸ | CDK2 | P24941 | 4/20 | 0.54 |
| ▸ | CDK1 | P06493 | 2/20 | 0.54 |
| ▸ | CDK9 | P50750 | 2/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12952853 | 0.89 | GSK3B (0.74) | GSK3BCDK2CCNE1 | |
| SCHEMBL14582522 | 0.89 | GSK3B (0.74) | GSK3BCDK2CCNE1 | |
| SCHEMBL14347821 | 0.89 | GSK3B (0.74) | GSK3BCDK2CCNE1 | |
| SCHEMBL13305383 | 0.89 | GSK3B (0.56) | GSK3BCDK2CDK1CDK9CDK5 | |
| SCHEMBL13305708 | 0.87 | GSK3B (0.57) | GSK3BCDK2CDK1CDK9CDK5 | |
| SCHEMBL14545811 | 0.85 | GSK3B (0.52) | GSK3BCDK2CDK1CDK9CDK5 | |
| SCHEMBL14347823 | 0.82 | GSK3B (0.71) | GSK3BCDK2CDK1CDK9CDK5 | |
| SCHEMBL13304607 | 0.81 | GSK3B (0.79) | GSK3BCDK2CHEK1CCNE1 | |
| SCHEMBL14050830 | 0.80 | GSK3B (0.68) | GSK3BCDK2CHEK1CCNE1 | |
| SCHEMBL14545919 | 0.79 | GSK3B (0.54) | GSK3BCDK2CHEK1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |