Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.53 |
| ▸ | GPR183 | P32249 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.44 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.44 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247041 | 0.89 | GPR183 (0.59) | KMT2AHRH4GPR183MEN1IP6K1 | |
| SCHEMBL3252765 | 0.81 | HRH4 (0.58) | KMT2AHRH4GPR183MEN1IP6K1 | |
| SCHEMBL3255524 | 0.75 | HRH4 (0.58) | KMT2AHRH4GPR183IP6K1IP6K3 | |
| SCHEMBL2351433 | 0.74 | HRH4 (0.78) | KMT2AHRH4MEN1NPC1RAB9A | |
| SCHEMBL2398699 | 0.74 | GPR183 (0.57) | KMT2AHRH4GPR183MEN1 | |
| SCHEMBL4982133 | 0.73 | IP6K1 (0.54) | KMT2AIP6K1IP6K3IP6K2MAPT | |
| SCHEMBL1949004 | 0.73 | IP6K1 (0.54) | KMT2AIP6K1IP6K3IP6K2MAPT | |
| SCHEMBL2347252 | 0.73 | HRH4 (0.76) | KMT2AHRH4MEN1NPC1RAB9A | |
| SCHEMBL3254801 | 0.72 | KMT2A (0.44) | KMT2AHRH4GPR183MEN1IP6K1 | |
| SCHEMBL2735825 | 0.71 | HRH4 (0.72) | KMT2AHRH4MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102207-B1 | SPIRO-PIPERIDINE DERIVATIVES AS VIA RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-06-02 | — | — | EP | disclosed |