Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.51 |
| ▸ | CDK2 | P24941 | 10/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13309084 | 0.90 | KDM4E (0.40) | GSK3BCDK2KDM4ETP53POLB | |
| SCHEMBL11931063 | 0.88 | GSK3B (0.54) | GSK3BCDK2CCNE1CHEK1CCNA2 | |
| SCHEMBL13308741 | 0.87 | GSK3B (0.57) | GSK3BCDK2CCNE1CHEK1CCNA2 | |
| SCHEMBL11931064 | 0.85 | GSK3B (0.55) | GSK3BCDK2CCNE1CHEK1CCNA2 | |
| SCHEMBL13309248 | 0.85 | GSK3B (0.54) | GSK3BCDK2CCNE1CHEK1CCNA2 | |
| SCHEMBL13308745 | 0.85 | GSK3B (0.54) | GSK3BCDK2CCNE1CHEK1CCNA2 | |
| SCHEMBL11931060 | 0.85 | GSK3B (0.58) | GSK3BCDK2CCNE1CHEK1CCNA2 | |
| SCHEMBL13885069 | 0.84 | GSK3B (0.52) | GSK3BCDK2CCNE1CHEK1CCNA2 | |
| SCHEMBL13885123 | 0.84 | GSK3B (0.54) | GSK3BCDK2CCNE1CHEK1CCNA2 | |
| SCHEMBL13885081 | 0.84 | GSK3B (0.53) | GSK3BCDK2CCNE1CHEK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934224-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS FOR THE TREATMENT OF CANCER | SCHERING CORP (US) | 2010-06-09 | — | — | EP | disclosed |