Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.49 |
| ▸ | EGFR | P00533 | 5/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13310060 | 0.90 | KDR (0.51) | KDRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13310046 | 0.88 | KDR (0.56) | KDRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20752924 | 0.82 | KDR (0.49) | KDRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20752912 | 0.82 | KDR (0.49) | KDRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20752925 | 0.82 | KDR (0.49) | KDRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL535218 | 0.81 | KDR (0.53) | KDRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13310048 | 0.80 | EGFR (0.58) | KDREGFRSRCBRAFFGFR1 | |
| SCHEMBL535303 | 0.78 | EGFR (0.59) | KDRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL535118 | 0.78 | EGFR (0.49) | KDRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL535365 | 0.77 | EGFR (0.50) | KDRHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10208062-B2 | Macrocyclic quinazole derivatives and their use as MTKI | JANSSEN PHARMACEUTICA NV (BE) | 2019-02-19 | — | — | US | disclosed |
| US-20170320894-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-09 | — | — | US | disclosed |
| US-9688691-B2 | Macrocyclic quinazole derivatives and their use as MTKI | JANSSEN PHARMACEUTICA NV (BE) | 2017-06-27 | — | — | US | disclosed |
| US-20140256714-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-11 | — | — | US | disclosed |
| US-20100152174-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | JANSSEN-CILAG (FR) | 2010-06-17 | — | — | US | disclosed |
| US-20100152174-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | JANSSEN-CILAG (FR) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256714-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | NR1I3, NR3C2, NR1I2 | KDR 2610/4885HDAC3 193/4885HDAC4 1205/4885 |
| US-20100152174-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | NR1I3, NR1I2, NR3C2 | KDR 2757/4885HDAC3 143/4885HDAC4 974/4885 |
| US-20170320894-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | NR1I3, NR3C2, NR1I2 | KDR 2610/4885HDAC3 193/4885HDAC4 1205/4885 |
| US-10208062-B2 | Macrocyclic quinazole derivatives and their use as MTKI | NR1I3, NR3C2, NR1I2 | KDR 2610/4885HDAC3 193/4885HDAC4 1205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.