Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.47 |
| ▸ | EGFR | P00533 | 6/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | KIF5B | P33176 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 12/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 12/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 12/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 12/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 12/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 12/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13310076 | 0.90 | KDR (0.45) | KDREGFRRETKIF5BHDAC3 | |
| SCHEMBL13310077 | 0.89 | HDAC3 (0.51) | KDRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20752920 | 0.81 | KDR (0.51) | KDREGFRHDAC3HDAC4HDAC1 | |
| SCHEMBL20752910 | 0.81 | KDR (0.51) | KDREGFRHDAC3HDAC4HDAC1 | |
| SCHEMBL20752914 | 0.81 | KDR (0.51) | KDREGFRHDAC3HDAC4HDAC1 | |
| SCHEMBL13310083 | 0.77 | SRC (0.53) | KDREGFRSRC | |
| SCHEMBL535751 | 0.76 | HDAC3 (0.48) | KDREGFRRETKIF5BHDAC3 | |
| SCHEMBL13310085 | 0.76 | AURKA (0.54) | KDREGFRRETMAPTSRC | |
| SCHEMBL535675 | 0.75 | KDR (0.48) | KDREGFRRETKIF5BHDAC3 | |
| SCHEMBL535716 | 0.75 | KDR (0.48) | KDREGFRRETKIF5BHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10208062-B2 | Macrocyclic quinazole derivatives and their use as MTKI | JANSSEN PHARMACEUTICA NV (BE) | 2019-02-19 | — | — | US | disclosed |
| US-20170320894-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-09 | — | — | US | disclosed |
| US-9688691-B2 | Macrocyclic quinazole derivatives and their use as MTKI | JANSSEN PHARMACEUTICA NV (BE) | 2017-06-27 | — | — | US | disclosed |
| US-20140256714-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-11 | — | — | US | disclosed |
| US-20100152174-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | JANSSEN-CILAG (FR) | 2010-06-17 | — | — | US | disclosed |
| US-20100152174-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | JANSSEN-CILAG (FR) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256714-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | NR1I3, NR3C2, NR1I2 | KDR 2610/4885EGFR 2929/4885RET 1558/4885 |
| US-20100152174-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | NR1I3, NR1I2, NR3C2 | KDR 2757/4885EGFR 2407/4885RET 1211/4885 |
| US-20170320894-A1 | MACROCYCLIC QUINAZOLE DERIVATIVES AND THEIR USE AS MTKI | NR1I3, NR3C2, NR1I2 | KDR 2610/4885EGFR 2929/4885RET 1558/4885 |
| US-10208062-B2 | Macrocyclic quinazole derivatives and their use as MTKI | NR1I3, NR3C2, NR1I2 | KDR 2610/4885EGFR 2929/4885RET 1558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.