Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 18/20 | 0.78 |
| ▸ | SCN3A | Q9NY46 | 9/20 | 0.78 |
| ▸ | SCN1A | P35498 | 1/20 | 0.72 |
| ▸ | SCN4A | P35499 | 1/20 | 0.72 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.72 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.72 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.72 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.72 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.72 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.70 |
| ▸ | MAOB | P27338 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13311070 | 0.89 | KCNH2 (0.68) | KCNH2SCN3ASCN1ASCN4ASCN7A | |
| SCHEMBL2833529 | 0.88 | KCNH2 (1.00) | KCNH2SCN3ASCN1ASCN4ASCN7A | |
| Hydrochloric Acid SCHEMBL2833631 | 0.87 | KCNH2 (0.98) | KCNH2SCN3ASCN1ASCN4ASCN7A | |
| SCHEMBL2832377 | 0.86 | KCNH2 (1.00) | KCNH2SCN3ASCN1ASCN4ASCN7A | |
| Hydrochloric Acid SCHEMBL2830685 | 0.85 | KCNH2 (0.98) | KCNH2SCN3ASCN1ASCN4ASCN7A | |
| Vixotrigine SCHEMBL862457 | 0.84 | KCNH2 (1.00) | KCNH2SCN3ASCN1ASCN4ASCN7A | |
| Vixotrigine SCHEMBL311438 | 0.84 | KCNH2 (1.00) | KCNH2SCN3ASCN1ASCN4ASCN7A | |
| Vixotrigine SCHEMBL311437 | 0.84 | KCNH2 (1.00) | KCNH2SCN3ASCN1ASCN4ASCN7A | |
| Vixotrigine SCHEMBL862301 | 0.84 | KCNH2 (1.00) | KCNH2SCN3ASCN1ASCN4ASCN7A | |
| Vixotrigine SCHEMBL840590 | 0.84 | KCNH2 (1.00) | KCNH2SCN3ASCN1ASCN4ASCN7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943216-B1 | PROLINAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GLAXO GROUP LTD (GB) | 2010-06-30 | — | — | EP | disclosed |
| WO-2007042250-A1 | PROLINAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |