Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 12/20 | 0.57 |
| ▸ | ABL1 | P00519 | 10/20 | 0.57 |
| ▸ | SRC | P12931 | 9/20 | 0.57 |
| ▸ | KDR | P35968 | 6/20 | 0.57 |
| ▸ | INSR | P06213 | 5/20 | 0.57 |
| ▸ | LCK | P06239 | 5/20 | 0.57 |
| ▸ | KIT | P10721 | 5/20 | 0.57 |
| ▸ | RET | P07949 | 4/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.57 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.57 |
| ▸ | LYN | P07948 | 4/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.57 |
| ▸ | FLT1 | P17948 | 4/20 | 0.57 |
| ▸ | FLT3 | P36888 | 4/20 | 0.57 |
| ▸ | JAK2 | O60674 | 3/20 | 0.57 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.57 |
| ▸ | CSF1R | P07333 | 3/20 | 0.57 |
| ▸ | MET | P08581 | 3/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13314412 | 0.93 | IGF1R (0.56) | IGF1RABL1SRCKDRINSR | |
| SCHEMBL13314413 | 0.83 | SRC (0.54) | IGF1RABL1SRCKDRINSR | |
| SCHEMBL13314405 | 0.83 | IGF1R (0.61) | IGF1RABL1SRCKDRINSR | |
| SCHEMBL13314339 | 0.83 | IGF1R (0.68) | IGF1RABL1SRCKDRINSR | |
| SCHEMBL13314318 | 0.82 | ABL1 (0.61) | IGF1RABL1SRCKDRINSR | |
| SCHEMBL13314317 | 0.82 | EGFR (0.74) | IGF1RABL1SRCKDRINSR | |
| SCHEMBL13314316 | 0.82 | SRC (0.54) | IGF1RABL1SRCKDRINSR | |
| SCHEMBL13314417 | 0.82 | ABL1 (0.56) | IGF1RABL1SRCKDRINSR | |
| SCHEMBL13314360 | 0.81 | SRC (0.55) | IGF1RABL1SRCKDRINSR | |
| SCHEMBL13314393 | 0.81 | RIPK2 (0.63) | IGF1RABL1SRCKDRINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160356-A1 | NOVEL CYCLOBUTYL COMPOUNDS AS KINASE INHIBITORS | MERCK PATENT GESELLSCHAFT (DE) | 2010-06-24 | — | — | US | disclosed |
| US-20100160356-A1 | NOVEL CYCLOBUTYL COMPOUNDS AS KINASE INHIBITORS | MERCK PATENT GESELLSCHAFT (DE) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160356-A1 | NOVEL CYCLOBUTYL COMPOUNDS AS KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K2 | IGF1R 645/4885ABL1 180/4885SRC 266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.