Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SGK1 | O00141 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | PRKCB | P05771 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.48 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.48 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | NEK3 | P51956 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13315250 | 0.87 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11NAMPT | |
| SCHEMBL3553716 | 0.81 | MAPK14 (0.56) | MAPK14SGK1MAPK13DAPK3RIPK2 | |
| SCHEMBL13315251 | 0.80 | RPS6KB1 (0.53) | MAPK14RPS6KB1NAMPT | |
| SCHEMBL3541451 | 0.78 | MAPK14 (0.65) | MAPK14SGK1MAPK13DAPK3RIPK2 | |
| SCHEMBL3241483 | 0.76 | MAPK14 (0.72) | MAPK14SGK1MAPK13DAPK3RIPK2 | |
| SCHEMBL3553191 | 0.73 | MAPK14 (0.54) | MAPK14SGK1MAPK13DAPK3RIPK2 | |
| SCHEMBL3545979 | 0.72 | MAPK14 (0.79) | MAPK14SGK1MAPK13DAPK3RIPK2 | |
| SCHEMBL13315252 | 0.71 | MAPK14 (0.51) | MAPK14SGK1MAPK13DAPK3RIPK2 | |
| SCHEMBL3546817 | 0.71 | MAPK14 (0.77) | MAPK14SGK1MAPK13DAPK3RIPK2 | |
| SCHEMBL3544859 | 0.71 | MEN1 (0.60) | MAPK14RPS6KB1NAMPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7741479-B2 | Urea inhibitors of MAP kinases | LOCUS PHARMACEUTICALS, INC. (US) | 2010-06-22 | — | — | US | disclosed |