Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 16/20 | 0.45 |
| ▸ | ICOSLG | O75144 | 10/20 | 0.45 |
| ▸ | ICOS | Q9Y6W8 | 10/20 | 0.45 |
| ▸ | IKBKB | O14920 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12619340 | 1.00 | CHUK (0.45) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL12619364 | 0.93 | CHUK (0.44) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL13315654 | 0.93 | CHUK (0.44) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL12653179 | 0.91 | CHUK (0.37) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL12619290 | 0.88 | CHUK (0.55) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL1796905 | 0.88 | CHUK (0.55) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL12653322 | 0.85 | CHUK (0.38) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL13349258 | 0.80 | CHUK (0.44) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL12619282 | 0.77 | ICOSLG (0.63) | CHUKICOSLGICOSIKBKBMEN1 | |
| SCHEMBL1800650 | 0.77 | ICOSLG (0.63) | CHUKICOSLGICOSIKBKBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7727985-B2 | Beta-carbolines useful for treating inflammatory disease | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-06-01 | — | — | US | disclosed |