Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.57 |
| ▸ | JAK2 | O60674 | 12/20 | 0.57 |
| ▸ | JAK1 | P23458 | 8/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13330241 | 0.89 | JAK3 (0.59) | JAK3JAK2JAK1 | |
| SCHEMBL2377282 | 0.77 | JAK3 (0.58) | JAK3JAK2JAK1 | |
| SCHEMBL2377027 | 0.77 | JAK3 (0.69) | JAK3JAK2JAK1 | |
| SCHEMBL2377517 | 0.77 | JAK2 (0.70) | JAK3JAK2JAK1 | |
| SCHEMBL2377752 | 0.77 | JAK2 (0.56) | JAK3JAK2JAK1 | |
| SCHEMBL2377072 | 0.76 | JAK3 (0.69) | JAK3JAK2JAK1 | |
| SCHEMBL2376721 | 0.76 | JAK2 (0.61) | JAK3JAK2JAK1 | |
| SCHEMBL2377479 | 0.76 | JAK3 (0.52) | JAK3JAK2JAK1 | |
| SCHEMBL2377190 | 0.76 | JAK3 (0.72) | JAK3JAK2JAK1 | |
| SCHEMBL2378478 | 0.76 | JAK2 (0.52) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063634-A1 | PYRROLOPYRAZINYL UREA KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-10 | — | — | WO | disclosed |