Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13331097 | 0.90 | S1PR1 (0.34) | S1PR1S1PR5 | |
| SCHEMBL3343532 | 0.85 | CNR2 (0.34) | S1PR1S1PR5CNR2CNR1 | |
| SCHEMBL3342731 | 0.82 | CNR2 (0.33) | S1PR1S1PR5CNR2CNR1 | |
| SCHEMBL13330803 | 0.82 | CNR2 (0.33) | S1PR1CNR2CNR1 | |
| SCHEMBL13303833 | 0.82 | SMN1; SMN2 (0.39) | S1PR1CNR2CNR1HDAC1HDAC8 | |
| SCHEMBL3342478 | 0.81 | S1PR1 (0.37) | S1PR1S1PR5CNR2CNR1KIT | |
| SCHEMBL3340738 | 0.80 | S1PR1 (0.37) | S1PR1S1PR5CNR2CNR1 | |
| SCHEMBL3338104 | 0.78 | S1PR1 (0.38) | S1PR1S1PR5 | |
| SCHEMBL3340282 | 0.76 | S1PR1 (0.38) | S1PR1S1PR5 | |
| SCHEMBL3345636 | 0.75 | SMN1; SMN2 (0.40) | S1PR1S1PR5CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010065760-A1 | IMIDAZO [1,2A] PYRIDINE DERIVATIVES, THEIR USE AS S1P1 AGONISTS AND METHODS FOR THEIR PRODUCTION | EXELIXIS, INC. (US) | 2010-06-10 | — | — | WO | disclosed |