Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 8/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 8/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 8/20 | 0.43 |
| ▸ | PDE2A | O00408 | 5/20 | 0.43 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9608339 | 0.81 | PDE1A (0.48) | PDE1APDE1BPDE1CPDE2ASLC16A1 | |
| SCHEMBL2455867 | 0.78 | PDE1A (0.49) | PDE1APDE1BPDE1CPDE2ASLC16A1 | |
| SCHEMBL2461101 | 0.77 | PDE1A (0.50) | PDE1APDE1BPDE1CPDE2ASLC16A1 | |
| SCHEMBL9608351 | 0.68 | PDE1A (0.44) | PDE1APDE1BPDE1CPDE2ASLC16A1 | |
| SCHEMBL9608334 | 0.65 | PDE1B (0.52) | PDE1APDE1BPDE1CPDE2ASLC16A1 | |
| SCHEMBL2462419 | 0.65 | PDE1A (0.46) | PDE1APDE1BPDE1CPDE2ASLC16A1 | |
| SCHEMBL2453873 | 0.65 | PDE1A (0.48) | PDE1APDE1BPDE1CPDE2ASLC16A1 | |
| SCHEMBL2458000 | 0.64 | PDE1A (0.52) | PDE1APDE1BPDE1CPDE2ASLC16A1 | |
| SCHEMBL9608330 | 0.64 | PDE1A (0.42) | PDE1APDE1BPDE1CPDE2ASLC16A1 | |
| SCHEMBL2461370 | 0.63 | PDE1A (0.49) | PDE1APDE1BPDE1CPDE2ASLC16A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010065147-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2010-06-10 | — | — | WO | disclosed |