Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.41 |
| ▸ | JAK2 | O60674 | 5/20 | 0.41 |
| ▸ | JAK1 | P23458 | 5/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | GHSR | Q92847 | 3/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15355506 | 0.91 | JAK3 (0.52) | JAK3JAK2JAK1IRAK4TYK2 | |
| SCHEMBL2504218 | 0.91 | JAK3 (0.52) | JAK3JAK2JAK1IRAK4TYK2 | |
| SCHEMBL2480542 | 0.82 | STAT6 (0.54) | JAK3JAK2JAK1IRAK4TYK2 | |
| SCHEMBL2480543 | 0.82 | STAT6 (0.54) | JAK3JAK2JAK1IRAK4TYK2 | |
| SCHEMBL2474859 | 0.80 | JAK3 (0.56) | JAK3JAK2JAK1IRAK4TYK2 | |
| SCHEMBL2474857 | 0.80 | JAK3 (0.56) | JAK3JAK2JAK1IRAK4TYK2 | |
| SCHEMBL2476267 | 0.77 | JAK3 (0.54) | JAK3JAK2JAK1IRAK4TYK2 | |
| SCHEMBL12301541 | 0.76 | JAK3 (0.52) | JAK3JAK2JAK1IRAK4TYK2 | |
| SCHEMBL2478938 | 0.76 | STAT6 (0.61) | JAK3JAK2JAK1IRAK4TYK2 | |
| SCHEMBL2483540 | 0.75 | JAK3 (0.52) | JAK3JAK2JAK1IRAK4TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010061971-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | 興和株式会社 (JP) | 2010-06-03 | — | — | WO | disclosed |