Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 19/20 | 0.56 |
| ▸ | CD63 | P08962 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13337151 | 0.89 | SYK (0.65) | SYKCD63AURKA | |
| SCHEMBL2480322 | 0.88 | SYK (0.62) | SYKCD63 | |
| SCHEMBL2478489 | 0.78 | SYK (0.61) | SYKCD63 | |
| SCHEMBL13337418 | 0.78 | SYK (0.64) | SYKCD63AURKA | |
| SCHEMBL2481515 | 0.78 | SYK (0.65) | SYKCD63 | |
| SCHEMBL2483250 | 0.77 | SYK (0.77) | SYKCD63 | |
| SCHEMBL14648651 | 0.77 | SYK (0.65) | SYKCD63AURKA | |
| SCHEMBL2481474 | 0.76 | SYK (0.82) | SYKCD63 | |
| SCHEMBL2481163 | 0.76 | AURKA (0.76) | SYKCD63AURKA | |
| SCHEMBL2482697 | 0.76 | SYK (0.72) | SYKCD63 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068257-A1 | IMIDAZOPYRAZINE SYK INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | disclosed |