Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.63 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | ROS1 | P08922 | 1/20 | 0.55 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.55 |
| ▸ | BTK | Q06187 | 1/20 | 0.55 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.55 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2483838 | 0.86 | SYK (0.76) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL21471696 | 0.80 | SYK (0.67) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2480610 | 0.79 | SYK (0.84) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2479507 | 0.78 | SYK (0.72) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL21471529 | 0.78 | SYK (0.81) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2474143 | 0.78 | SYK (0.72) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL22067932 | 0.77 | SYK (0.74) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2478633 | 0.77 | SYK (0.80) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2474475 | 0.76 | SYK (0.78) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL15308150 | 0.76 | SYK (0.81) | SYKJAK2NTRK1ROS1CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068257-A1 | IMIDAZOPYRAZINE SYK INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | disclosed |