Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 13/20 | 0.60 |
| ▸ | RAF1 | P04049 | 7/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | BRAF | P15056 | 2/20 | 0.49 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.49 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL971526 | 0.85 | MAP2K1 (0.59) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL971525 | 0.85 | MAP2K1 (0.68) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL959270 | 0.79 | MAP2K1 (0.62) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL970190 | 0.79 | MAP2K1 (0.70) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL960703 | 0.78 | MAP2K1 (0.70) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL31980592 | 0.78 | MAP2K1 (0.70) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL12694056 | 0.78 | MAP2K1 (0.69) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL959667 | 0.75 | MAP2K1 (0.70) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL12917636 | 0.75 | MAP2K1 (1.00) | MAP2K1RAF1CYP2C9CYP3A4BRAF | |
| SCHEMBL960504 | 0.75 | MAP2K1 (0.65) | MAP2K1RAF1CYP2C9CYP3A4BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709664-B2 | Coumarin derivatives useful as TNFα inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-05-04 | — | — | US | disclosed |
| US-7709664-B2 | Coumarin derivatives useful as TNFα inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-05-04 | — | — | US | disclosed |