Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 1.00 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.77 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.77 |
| ▸ | FLT4 | P35916 | 3/20 | 0.77 |
| ▸ | FLT3 | P36888 | 3/20 | 0.77 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.77 |
| ▸ | RET | P07949 | 2/20 | 0.77 |
| ▸ | FLT1 | P17948 | 2/20 | 0.77 |
| ▸ | AXL | P30530 | 2/20 | 0.77 |
| ▸ | FRK | P42685 | 2/20 | 0.77 |
| ▸ | PLK4 | O00444 | 2/20 | 0.71 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.71 |
| ▸ | MET | P08581 | 2/20 | 0.71 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.71 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.71 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.71 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.71 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.71 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.71 |
| ▸ | AURKA | O14965 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1331121 | 0.93 | KDR (0.88) | KDRROCK2EPHA2FLT4FLT3 | |
| SCHEMBL1335340 | 0.89 | KDR (0.80) | KDRROCK2EPHA2FLT4FLT3 | |
| SCHEMBL1335352 | 0.87 | KDR (1.00) | KDRROCK2EPHA2FLT4FLT3 | |
| SCHEMBL1335486 | 0.87 | KDR (1.00) | KDRROCK2EPHA2FLT4FLT3 | |
| SCHEMBL1335220 | 0.86 | KDR (0.76) | KDRROCK2EPHA2FLT4FLT3 | |
| SCHEMBL1335403 | 0.85 | KDR (1.00) | KDRROCK2EPHA2FLT4FLT3 | |
| SCHEMBL1334387 | 0.85 | KDR (0.85) | KDRROCK2EPHA2FLT4FLT3 | |
| SCHEMBL1334360 | 0.85 | KDR (1.00) | KDRROCK2EPHA2FLT4FLT3 | |
| SCHEMBL1333715 | 0.84 | KDR (1.00) | KDRROCK2EPHA2FLT4FLT3 | |
| SCHEMBL1335520 | 0.84 | KDR (1.00) | KDRROCK2EPHA2FLT4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060287370-A1 | Isoindolinone kinase inhibitors | CURTIN MICHAEL L | 2006-12-21 | — | — | US | claimed |
| US-7129260-B2 | Isoindolinone kinase inhibitors | ABBOTT LABORATORIES (US) | 2006-10-31 | — | — | US | claimed |
| EP-1633710-A1 | ISOINDOLIN-1-ONE COMPOUNDS AS KINASE INHIBITORS | Abbott Laboratories (US) | 2006-03-15 | — | — | EP | claimed |
| US-20050026976-A1 | Isoindolinone kinase inhibitors | ABBOTT LABORATORIES | 2005-02-03 | — | — | US | claimed |
| WO-2004108672-A1 | ISOINDOLIN-1-ONE COMPOUNDS AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-12-16 | — | — | WO | claimed |
| US-20110275630-A1 | ISOINDOLINONE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2011-11-10 | — | — | US | disclosed |
| US-20100076051-A1 | ISOINDOLINONE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2010-03-25 | — | — | US | disclosed |
| US-20060287370-A1 | Isoindolinone kinase inhibitors | CURTIN MICHAEL L | 2006-12-21 | — | — | US | disclosed |
| US-7129260-B2 | Isoindolinone kinase inhibitors | ABBOTT LABORATORIES (US) | 2006-10-31 | — | — | US | disclosed |
| US-20050026976-A1 | Isoindolinone kinase inhibitors | ABBOTT LABORATORIES | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287370-A1 | Isoindolinone kinase inhibitors | ABL1, LCK, MAP3K7 | KDR 527/4885ROCK2 264/4885EPHA2 979/4885 |
| US-20050026976-A1 | Isoindolinone kinase inhibitors | ABL1, LCK, MAP3K7 | KDR 527/4885ROCK2 264/4885EPHA2 979/4885 |
| US-20100076051-A1 | ISOINDOLINONE KINASE INHIBITORS | ABL1, LCK, MAP3K7 | KDR 527/4885ROCK2 264/4885EPHA2 979/4885 |
| US-20110275630-A1 | ISOINDOLINONE KINASE INHIBITORS | MAP3K7, MAP3K5, MAP3K20 | KDR 909/4885ROCK2 316/4885EPHA2 1880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.