Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | BCL6 | P41182 | 2/20 | 0.36 |
| ▸ | CCNK | O75909 | 5/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1334449 | 1.00 | GRM5 (0.44) | GRM5CDK7CDK9MAPK8CDK4 | |
| SCHEMBL1333361 | 0.86 | LRRK2 (0.38) | GRM5CDK7CDK9MAPK8CCNK | |
| SCHEMBL1333372 | 0.86 | LRRK2 (0.38) | GRM5CDK7CDK9MAPK8CCNK | |
| SCHEMBL1333363 | 0.86 | LRRK2 (0.38) | GRM5CDK7CDK9MAPK8CCNK | |
| SCHEMBL1334190 | 0.84 | GRM5 (0.39) | GRM5CDK7CDK9CDK4GSK3B | |
| SCHEMBL1334188 | 0.84 | GRM5 (0.39) | GRM5CDK7CDK9CDK4GSK3B | |
| SCHEMBL1332220 | 0.81 | GRM5 (0.47) | GRM5CDK7CDK9MAPK8CDK4 | |
| SCHEMBL1332223 | 0.81 | GRM5 (0.47) | GRM5CDK7CDK9MAPK8CDK4 | |
| SCHEMBL1334293 | 0.80 | GRM5 (0.50) | GRM5CDK7CDK9MAPK8CDK4 | |
| SCHEMBL1334291 | 0.80 | GRM5 (0.50) | GRM5CDK7CDK9MAPK8CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513242-B2 | Pyrimidine compounds and methods of making and using same | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2013-08-20 | — | — | US | disclosed |
| US-20110281873-A1 | Pyrimidine Compounds and Methods of Making and Using Same | CYSTIC FIBROSIS FOUNDATION | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281873-A1 | Pyrimidine Compounds and Methods of Making and Using Same | CFTR, GPR17, TYMS | GRM5 2764/4885CDK7 2163/4885CDK9 1560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.