Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 7/20 | 0.69 |
| ▸ | LCK | P06239 | 6/20 | 0.69 |
| ▸ | CSF1R | P07333 | 6/20 | 0.69 |
| ▸ | LYN | P07948 | 6/20 | 0.69 |
| ▸ | KIT | P10721 | 6/20 | 0.69 |
| ▸ | BLK | P51451 | 6/20 | 0.69 |
| ▸ | SRC | P12931 | 5/20 | 0.69 |
| ▸ | AURKA | O14965 | 5/20 | 0.69 |
| ▸ | MET | P08581 | 5/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.69 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.69 |
| ▸ | EPHA2 | P29317 | 5/20 | 0.69 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.69 |
| ▸ | FLT3 | P36888 | 4/20 | 0.69 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.69 |
| ▸ | LIMK1 | P53667 | 4/20 | 0.69 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.69 |
| ▸ | INSR | P06213 | 4/20 | 0.69 |
| ▸ | MARK3 | P27448 | 4/20 | 0.69 |
| ▸ | NEK2 | P51955 | 4/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12677672 | 0.91 | KDR (0.63) | FLT1LCKCSF1RLYNKIT | |
| SCHEMBL3525299 | 0.87 | FLT1 (0.64) | FLT1LCKCSF1RLYNKIT | |
| SCHEMBL1378518 | 0.87 | KDR (0.79) | FLT1LCKCSF1RLYNKIT | |
| SCHEMBL3530181 | 0.81 | FLT1 (0.68) | FLT1LCKCSF1RLYNKIT | |
| SCHEMBL3532643 | 0.81 | KDR (0.75) | FLT1LCKCSF1RLYNKIT | |
| SCHEMBL1379004 | 0.81 | KDR (0.77) | FLT1LCKCSF1RLYNKIT | |
| SCHEMBL3530388 | 0.80 | PLK4 (0.76) | FLT1LCKCSF1RLYNKIT | |
| SCHEMBL12677446 | 0.80 | AURKA (0.59) | FLT1LCKCSF1RLYNKIT | |
| SCHEMBL3526371 | 0.79 | KDR (0.73) | FLT1LCKCSF1RLYNKIT | |
| SCHEMBL27640553 | 0.79 | AURKA (0.58) | FLT1LCKCSF1RLYNKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737160-B2 | Thienopyridine and furopyridine kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2010-06-15 | — | — | US | disclosed |
| EP-1648905-B1 | THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS | ABBOTT LAB (US) | 2008-12-31 | — | — | EP | disclosed |
| US-20070155776-A1 | THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS | ABBVIE INC. | 2007-07-05 | — | — | US | disclosed |
| US-7202363-B2 | Thienopyridine and furopyridine kinase inhibitors | ABBOTT LABORATORIES (US) | 2007-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155776-A1 | THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS | ABL1, ERBB2, LCK | FLT1 613/4885LCK 3/4885CSF1R 1197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.