Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 18/20 | 0.58 |
| ▸ | CHUK | O15111 | 13/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12344332 | 0.86 | IKBKB (0.67) | IKBKBCHUK | |
| SCHEMBL2784605 | 0.84 | IKBKB (0.54) | IKBKBCHUK | |
| SCHEMBL13348700 | 0.83 | CHUK (0.51) | IKBKBCHUK | |
| SCHEMBL2767257 | 0.83 | IKBKB (0.81) | IKBKBCHUK | |
| SCHEMBL12344621 | 0.83 | IKBKB (0.58) | IKBKBCHUKCSF1R | |
| SCHEMBL12344388 | 0.83 | IKBKB (0.71) | IKBKBCHUK | |
| SCHEMBL13348635 | 0.80 | IKBKB (0.49) | IKBKBCHUK | |
| SCHEMBL13348799 | 0.80 | IKBKB (0.47) | IKBKBCHUKCSF1R | |
| SCHEMBL12344509 | 0.79 | IKBKB (0.50) | IKBKBCHUK | |
| SCHEMBL13348701 | 0.79 | IKBKB (0.53) | IKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737279-B2 | 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-06-15 | — | — | US | disclosed |